Disease spread through contiguity and axonal tracts in primary lateral sclerosis.
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ABSTRACT:
SUBMITTER: Flynn L
PROVIDER: S-EPMC4545964 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
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Disease spread through contiguity and axonal tracts in primary lateral sclerosis.
Flynn Lauren L Stephen Matthew M Floeter Mary Kay MK
Muscle & nerve 20140127 3
Our goal in this report was to determine whether symptom progression in primary lateral sclerosis (PLS) was consistent with disease spread through axonal pathways or contiguous cortical regions. The date of symptom onset in each limb and cranial region was obtained from 45 PLS patient charts. Each appearance of symptoms in a new body region was classified as axonal, contiguous, possibly contiguous, or unrelated, according to whether the somatotopic representations were adjacent in the cortex. Of ...[more]
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