Ontology highlight
ABSTRACT:
SUBMITTER: Yang Z
PROVIDER: S-EPMC4546326 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Yang Zhao Z Zhuan Bing B Yan Ying Y Jiang Simin S Wang Tao T
Biological research 20150822
<h4>Background</h4>Although numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the gene differential expression and copy number variation (CNV).<h4>Results</h4>A higher burden of the CNVs was found in 10-50 kb length. The 16 CNV-driven genes mainly located in chr 1 and chr 3 were enriched in immune response [e.g. complement factor H (CFH) and Fc fragme ...[more]