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Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival.

ABSTRACT: Feline mammary carcinomas (FMCs) are highly malignant. As the disease-free survival (DFS) and overall survival (OS) are short, prognostication is crucial. Copy-number variations (CNVs) analysis by next-generation sequencing serves to identify critical cancer-related genomic regions. Thirty-three female cats with FMCs were followed during two years after surgery. Tumours represented tubulopapillary and solid carcinomas encompassing six molecular subtypes. Regardless of the histopathological diagnosis, molecular subtypes showed important differences in survival. Luminal A tumours exhibited the highest DFS (p?=?0.002) and cancer-specific OS (p?=?0.001), and the lowest amount of CNVs (p?=?0.0001). In contrast, basal-like triple-negative FMCs had the worst outcome (DFS, p?

SUBMITTER: Granados-Soler JL

PROVIDER: S-EPMC6976565 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Analysis of Copy-Number Variations and Feline Mammary Carcinoma Survival.

Granados-Soler José Luis JL Bornemann-Kolatzki Kirsten K Beck Julia J Brenig Bertram B Schütz Ekkehard E Betz Daniela D Junginger Johannes J Hewicker-Trautwein Marion M Murua Escobar Hugo H Nolte Ingo I

Scientific reports 20200122 1

Feline mammary carcinomas (FMCs) are highly malignant. As the disease-free survival (DFS) and overall survival (OS) are short, prognostication is crucial. Copy-number variations (CNVs) analysis by next-generation sequencing serves to identify critical cancer-related genomic regions. Thirty-three female cats with FMCs were followed during two years after surgery. Tumours represented tubulopapillary and solid carcinomas encompassing six molecular subtypes. Regardless of the histopathological diagn ...[more]

PMID: 31969654

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