Ontology highlight
ABSTRACT:
SUBMITTER: Shinde R
PROVIDER: S-EPMC4546929 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Shinde Rahul R Shimoda Michiko M Chaudhary Kapil K Liu Haiyun H Mohamed Eslam E Bradley Jillian J Kandala Sridhar S Li Xia X Liu Kebin K McGaha Tracy L TL
Journal of immunology (Baltimore, Md. : 1950) 20150727 5
Humoral responses to nonproteinaceous Ags (i.e., T cell independent [TI]) are a key component of the early response to bacterial and viral infection and a critical driver of systemic autoimmunity. However, mechanisms that regulate TI humoral immunity are poorly defined. In this study, we report that B cell-intrinsic induction of the tryptophan-catabolizing enzyme IDO1 is a key mechanism limiting TI Ab responses. When Ido1(-/-) mice were immunized with TI Ags, there was a significant increase in ...[more]