Ontology highlight
ABSTRACT:
SUBMITTER: Tan HX
PROVIDER: S-EPMC6355240 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Tan Hyon-Xhi HX Jegaskanda Sinthujan S Juno Jennifer A JA Esterbauer Robyn R Wong Julius J Kelly Hannah G HG Liu Yi Y Tilmanis Danielle D Hurt Aeron C AC Yewdell Jonathan W JW Kent Stephen J SJ Wheatley Adam K AK
The Journal of clinical investigation 20190122 2
Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralizing antibody responses against highly diverse epitopes within the "head" of the viral hemagglutinin (HA) protein. There is increasing interest in redirecting immunity toward the more conserved HA stem or stalk as a means of broadening protective antibody responses. Here we examined HA stem-specific B cell and T follicular helper (Tfh) cell responses in the context of influenza infection and immuniz ...[more]