Ontology highlight
ABSTRACT:
SUBMITTER: Maqbool A
PROVIDER: S-EPMC4547098 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
eLife 20150825
Plants have evolved intracellular immune receptors to detect pathogen proteins known as effectors. How these immune receptors detect effectors remains poorly understood. Here we describe the structural basis for direct recognition of AVR-Pik, an effector from the rice blast pathogen, by the rice intracellular NLR immune receptor Pik. AVR-PikD binds a dimer of the Pikp-1 HMA integrated domain with nanomolar affinity. The crystal structure of the Pikp-HMA/AVR-PikD complex enabled design of mutatio ...[more]