Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC5752844 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Yang Xinru X Yang Fan F Wang Weiguang W Lin Guangzhong G Hu Zehan Z Han Zhifu Z Qi Yijun Y Zhang Liman L Wang Jiawei J Sui Sen-Fang SF Chai Jijie J
Cell research 20171128 1
The nucleotide-binding domain- and leucine-rich repeat (LRR)-containing proteins (NLRs) function as intracellular immune receptors to detect the presence of pathogen- or host-derived signals. The mechanisms of how NLRs sense their ligands remain elusive. Here we report the structure of a bacterial flagellin derivative in complex with the NLR proteins NAIP5 and NLRC4 determined by cryo-electron microscopy at 4.28 Å resolution. The structure revealed that the flagellin derivative forms two paralle ...[more]