Plasmodium falciparum genetic crosses in a humanized mouse model.
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ABSTRACT:
SUBMITTER: Vaughan AM
PROVIDER: S-EPMC4547688 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Publications
Plasmodium falciparum genetic crosses in a humanized mouse model.
Vaughan Ashley M AM Pinapati Richard S RS Cheeseman Ian H IH Camargo Nelly N Fishbaugher Matthew M Checkley Lisa A LA Nair Shalini S Hutyra Carolyn A CA Nosten François H FH Anderson Timothy J C TJ Ferdig Michael T MT Kappe Stefan H I SH
Nature methods 20150601 7
Genetic crosses of phenotypically distinct strains of the human malaria parasite Plasmodium falciparum are a powerful tool for identifying genes controlling drug resistance and other key phenotypes. Previous studies relied on the isolation of recombinant parasites from splenectomized chimpanzees, a research avenue that is no longer available. Here we demonstrate that human-liver chimeric mice support recovery of recombinant progeny for the identification of genetic determinants of parasite trait ...[more]
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