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Depression and quality of life before and after breast cancer diagnosis in older women from the Women's Health Initiative.


ABSTRACT: Distress and reduced quality of life (QOL) are common among people with cancer. No study has compared these variables after breast cancer diagnosis to pre-cancer diagnosis levels.Data on women with breast cancer 50 years of age or older (n?=?6949) were analyzed from the Women's Health Initiative (1993-2013). Health-related QOL (physical function, mental health) was measured using Rand-36. Depressive symptoms were measured with the six-item Center for Epidemiologic Studies Depression scale. Assessments occurred before and after the cancer diagnosis. Hierarchical linear modeling compared pre-cancer QOL and depressive symptoms to levels post-diagnosis and tested whether pre-cancer physical activity, stressful life events, sleep disturbance, and pain predicted post-diagnosis outcomes.Compared with pre-cancer levels, depressive symptoms increased (20.0% increase at 0-6 months, 12.9% increase at 6-12 months), while physical function (-3.882 points at 0-6 months, -3.545 at 6-12 months) and mental health decreased (-2.899 points at 0-6 months, -1.672 at 6-12 months) in the first year after diagnosis (all p?

SUBMITTER: Jones SM 

PROVIDER: S-EPMC4547920 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature

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Depression and quality of life before and after breast cancer diagnosis in older women from the Women's Health Initiative.

Jones Salene M W SM   LaCroix Andrea Z AZ   Li Wenjun W   Zaslavsky Oleg O   Wassertheil-Smoller Sylvia S   Weitlauf Julie J   Brenes Gretchen A GA   Nassir Rami R   Ockene Judith K JK   Caire-Juvera Graciela G   Danhauer Suzanne C SC  

Journal of cancer survivorship : research and practice 20150224 4


<h4>Purpose</h4>Distress and reduced quality of life (QOL) are common among people with cancer. No study has compared these variables after breast cancer diagnosis to pre-cancer diagnosis levels.<h4>Methods</h4>Data on women with breast cancer 50 years of age or older (n = 6949) were analyzed from the Women's Health Initiative (1993-2013). Health-related QOL (physical function, mental health) was measured using Rand-36. Depressive symptoms were measured with the six-item Center for Epidemiologic  ...[more]

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