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Frailty and health-related quality of life in older women with breast cancer.


ABSTRACT: PURPOSE:In older women, breast cancer and its treatment can have profound impact on their physical, mental, and social health, especially in frail patients. This study evaluated the association between frailty and long-term health-related quality of life (HRQOL) in older women undergoing breast cancer treatment. METHODS:Using the Carolina Senior Registry (CSR), participants with breast cancer were contacted to complete a follow-up HRQOL questionnaire (median 4 years). Baseline Geriatric Assessment (GA) variables were used to calculate the Carolina Frailty Index (CFI) and categorize participants as robust, pre-frail, or frail. Outcomes included HRQOL domains of physical function, social roles, fatigue, depression, anxiety, pain, and sleep disturbance assessed using PROMIS® instruments. Regression modeling compared outcomes between frailty groups using adjusted mean differences (AMD). RESULTS:Of 190 eligible patients, 63 completed follow-up HRQOL survey. Mean age was 70 years (range 65-86) and 91% were white. Based on the CFI, 49 (78%) patients were robust, 11 (18%) pre-frail, and 3 (5%) frail. After controlling for age and cancer stage, patients identified as pre-frail/frail reported worse physical function (AMD -?9.2, p?

SUBMITTER: Williams GR 

PROVIDER: S-EPMC6536366 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

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Frailty and health-related quality of life in older women with breast cancer.

Williams Grant R GR   Deal Allison M AM   Sanoff Hanna K HK   Nyrop Kirsten A KA   Guerard Emily J EJ   Pergolotti Mackenzi M   Shachar Shlomit S SS   Reeve Bryce B BB   Bensen Jeannette T JT   Choi Seul Ki SK   Muss Hyman B HB  

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20181127 7


<h4>Purpose</h4>In older women, breast cancer and its treatment can have profound impact on their physical, mental, and social health, especially in frail patients. This study evaluated the association between frailty and long-term health-related quality of life (HRQOL) in older women undergoing breast cancer treatment.<h4>Methods</h4>Using the Carolina Senior Registry (CSR), participants with breast cancer were contacted to complete a follow-up HRQOL questionnaire (median 4 years). Baseline Ger  ...[more]

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