Ontology highlight
ABSTRACT:
SUBMITTER: Welin ER
PROVIDER: S-EPMC4548807 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20150630 33
The combination of photoredox catalysis and enamine catalysis has enabled the development of an enantioselective α-cyanoalkylation of aldehydes. This synergistic catalysis protocol allows for the coupling of two highly versatile yet orthogonal functionalities, allowing rapid diversification of the oxonitrile products to a wide array of medicinally relevant derivatives and heterocycles. This methodology has also been applied to the total synthesis of the lignan natural product (-)-bursehernin. ...[more]