Dataset Information
Enantioselective ?-arylation of aldehydes via the productive merger of iodonium salts and organocatalysis.
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ABSTRACT:
SUBMITTER: Allen AE
PROVIDER: S-EPMC3082494 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Publications
Enantioselective α-arylation of aldehydes via the productive merger of iodonium salts and organocatalysis.
Journal of the American Chemical Society 20110309 12
The enantioselective α-arylation of aldehydes has been accomplished using diaryliodonium salts and a combination of copper and organic catalysts. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-formyl benzylic stereocenters, a valuable synthon for the production of medicinal agents. As one example, this new asymmetric protocol has been applied to the rapid synthesis of (S)-ketoprofen, a commercially successful oral and to ...[more]