Ontology highlight
ABSTRACT:
SUBMITTER: Zhu W
PROVIDER: S-EPMC6301098 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Zhu Wuqiang W Zhang Eric E Zhao Meng M Chong Zechen Z Fan Chengming C Tang Yawen Y Hunter Jervaughn D JD Borovjagin Anton V AV Walcott Gregory P GP Chen Jake Y JY Qin Gangjian G Zhang Jianyi J
Circulation 20181201 24
<h4>Background</h4>Rodent hearts can regenerate myocardium lost to apical resection or myocardial infarction for up to 7 days after birth, but whether a similar window for myocardial regeneration also exists in large mammals is unknown.<h4>Methods</h4>Acute myocardial infarction (AMI) was surgically induced in neonatal pigs on postnatal days 1, 2, 3, 7, and 14 (ie, the P1, P2, P3, P7, and P14 groups, respectively). Cardiac systolic function was evaluated before AMI and at 30 days post-AMI via tr ...[more]