Ontology highlight
ABSTRACT:
SUBMITTER: Carreno BM
PROVIDER: S-EPMC4549796 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20150402 6236
T cell immunity directed against tumor-encoded amino acid substitutions occurs in some melanoma patients. This implicates missense mutations as a source of patient-specific neoantigens. However, a systematic evaluation of these putative neoantigens as targets of antitumor immunity is lacking. Moreover, it remains unknown whether vaccination can augment such responses. We found that a dendritic cell vaccine led to an increase in naturally occurring neoantigen-specific immunity and revealed previo ...[more]