Ontology highlight
ABSTRACT:
SUBMITTER: Brightman SE
PROVIDER: S-EPMC7793607 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Journal of leukocyte biology 20200314 4
The goal of precision immunotherapy is to direct a patient's T cell response against the immunogenic mutations expressed on their tumors. Most immunotherapy approaches to-date have focused on MHC class I-restricted peptide epitopes by which cytotoxic CD8<sup>+</sup> T lymphocytes (CTL) can directly recognize tumor cells. This strategy largely overlooks the critical role of MHC class II-restricted CD4<sup>+</sup> T cells as both positive regulators of CTL and other effector cell types, and as dir ...[more]