Ontology highlight
ABSTRACT:
SUBMITTER: Maccani JZ
PROVIDER: S-EPMC4550511 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Maccani Jennifer Z J JZ Koestler Devin C DC Houseman E Andrés EA Armstrong David A DA Marsit Carmen J CJ Kelsey Karl T KT
Reproductive toxicology (Elmsford, N.Y.) 20150515
Adequate micronutrient intake, including manganese (Mn), is important for fetal development. Both Mn deficiencies and excess exposures are associated with later-life disease, and Mn accumulates in the placenta. Placental functional alterations may alter fetal programming and lifelong health, and we hypothesized that prenatal exposures to Mn may alter placental function through epigenetic mechanisms. Using Illumina's HumanMethylation450 BeadArray, DNA methylation of >485,000 CpG loci genome-wide ...[more]