Third trimester phthalate exposure is associated with DNA methylation of growth-related genes in human placenta.
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ABSTRACT:
SUBMITTER: Zhao Y
PROVIDER: S-EPMC5031987 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
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Third trimester phthalate exposure is associated with DNA methylation of growth-related genes in human placenta.
Zhao Yan Y Chen Jiao J Wang Xiu X Song Qi Q Xu Hui-Hui HH Zhang Yun-Hui YH
Scientific reports 20160922
Strong evidence implicates maternal phthalate exposure during pregnancy in contributing to adverse birth outcomes. Recent research suggests these effects might be mediated through the improper regulation of DNA methylation in offspring tissue. In this study, we examined associations between prenatal phthalate exposure and DNA methylation in human placenta. We recruited 181 mother-newborn pairs (80 fetal growth restriction newborns, 101 normal newborns) in Wenzhou, China and measured third trimes ...[more]
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