Ontology highlight
ABSTRACT:
SUBMITTER: Dong SH
PROVIDER: S-EPMC4550811 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Dong Shi-Hui SH Tang Weixin W Lukk Tiit T Yu Yi Y Nair Satish K SK van der Donk Wilfred A WA
eLife 20150730
The enterococcal cytolysin is a virulence factor consisting of two post-translationally modified peptides that synergistically kill human immune cells. Both peptides are made by CylM, a member of the LanM lanthipeptide synthetases. CylM catalyzes seven dehydrations of Ser and Thr residues and three cyclization reactions during the biosynthesis of the cytolysin large subunit. We present here the 2.2 Å resolution structure of CylM, the first structural information on a LanM. Unexpectedly, the stru ...[more]