Ontology highlight
ABSTRACT:
SUBMITTER: Estrada P
PROVIDER: S-EPMC7310518 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nature chemical biology 20170417 6
Reactions that activate carboxylates through acyl-adenylate intermediates are found throughout biology and include acyl- and aryl-CoA synthetases and tRNA synthetases. Here we describe the characterization of Aquifex aeolicus BioW, which represents a new protein fold within the superfamily of adenylating enzymes. Substrate-bound structures identified the enzyme active site and elucidated the mechanistic strategy for conjugating CoA to the seven-carbon α,ω-dicarboxylate pimelate, a biotin precurs ...[more]