Ontology highlight
ABSTRACT:
SUBMITTER: Puimege L
PROVIDER: S-EPMC4551340 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
EMBO molecular medicine 20150801 8
TNF is a central actor during inflammation and a well-recognized drug target for inflammatory diseases. We found that the mouse strain SPRET/Ei, known for extreme and dominant resistance against TNF-induced shock, displays weak expression of TNF receptor 1 protein (TNFR1) but normal mRNA expression, a trait genetically linked to the major TNFR1 coding gene Tnfrsf1a and to a locus harbouring the predicted TNFR1-regulating miR-511. This miRNA is a genuine TNFR1 regulator in cells. In mice, overexp ...[more]