Ontology highlight
ABSTRACT:
SUBMITTER: Preston GC
PROVIDER: S-EPMC4551349 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Preston Gavin C GC Sinclair Linda V LV Kaskar Aneesa A Hukelmann Jens L JL Navarro Maria N MN Ferrero Isabel I MacDonald H Robson HR Cowling Victoria H VH Cantrell Doreen A DA
The EMBO journal 20150701 15
Myc controls the metabolic reprogramming that supports effector T cell differentiation. The expression of Myc is regulated by the T cell antigen receptor (TCR) and pro-inflammatory cytokines such as interleukin-2 (IL-2). We now show that the TCR is a digital switch for Myc mRNA and protein expression that allows the strength of the antigen stimulus to determine the frequency of T cells that express Myc. IL-2 signalling strength also directs Myc expression but in an analogue process that fine-tun ...[more]