Ontology highlight
ABSTRACT:
SUBMITTER: Lee IG
PROVIDER: S-EPMC4551927 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Lee In-Gyun IG Lee Sang Jae SJ Chae Susanna S Lee Ki-Young KY Kim Ji-Hun JH Lee Bong-Jin BJ
Nucleic acids research 20150706 15
Toxin-antitoxin (TA) systems play important roles in bacterial physiology, such as multidrug tolerance, biofilm formation, and arrest of cellular growth under stress conditions. To develop novel antimicrobial agents against tuberculosis, we focused on VapBC systems, which encompass more than half of TA systems in Mycobacterium tuberculosis. Here, we report that theMycobacterium tuberculosis VapC30 toxin regulates cellular growth through both magnesium and manganese ion-dependent ribonuclease act ...[more]