Ontology highlight
ABSTRACT:
SUBMITTER: Choi HW
PROVIDER: S-EPMC4551988 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Choi Hyun Woo HW Kim Jong Soo JS Hong Yean Ju YJ Song Hyuk H Seo Han Geuk HG Do Jeong Tae JT
Scientific reports 20150828
Recently, induced pluripotent stem cells (iPSCs) have been generated in vivo from reprogrammable mice. These in vivo iPSCs display features of totipotency, i.e., they differentiate into the trophoblast lineage, as well as all 3 germ layers. Here, we developed a new reprogrammable mouse model carrying an Oct4-GFP reporter gene to facilitate the detection of reprogrammed pluripotent stem cells. Without doxycycline administration, some of the reprogrammable mice developed aggressively growing terat ...[more]