Ontology highlight
ABSTRACT:
SUBMITTER: Schmidt LH
PROVIDER: S-EPMC4552388 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Schmidt Lars Henning LH Kümmel Andreas A Görlich Dennis D Mohr Michael M Bröckling Sebastian S Mikesch Jan Henrik JH Grünewald Inga I Marra Alessandro A Schultheis Anne M AM Wardelmann Eva E Müller-Tidow Carsten C Spieker Tilmann T Schliemann Christoph C Berdel Wolfgang E WE Wiewrodt Rainer R Hartmann Wolfgang W
PloS one 20150827 8
<h4>Background</h4>Immunotherapy can become a crucial therapeutic option to improve prognosis for lung cancer patients. First clinical trials with therapies targeting the programmed cell death receptor PD-1 and its ligand PD-L1 have shown promising results in several solid tumors. However, in lung cancer the diagnostic, prognostic and predictive value of these immunologic factors remains unclear.<h4>Method</h4>The impact of both factors was evaluated in a study collective of 321 clinically well- ...[more]