Genetic determinants of anti-malarial acquired immunity in a large multi-centre study.

ABSTRACT:

Background

Many studies report associations between human genetic factors and immunity to malaria but few have been reliably replicated. These studies are usually country-specific, use small sample sizes and are not directly comparable due to differences in methodologies. This study brings together samples and data collected from multiple sites across Africa and Asia to use standardized methods to look for consistent genetic effects on anti-malarial antibody levels.

Methods

Sera, DNA samples and clinical data were collected from 13,299 individuals from ten sites in Senegal, Mali, Burkina Faso, Sudan, Kenya, Tanzania, and Sri Lanka using standardized methods. DNA was extracted and typed for 202 Single Nucleotide Polymorphisms with known associations to malaria or antibody pro

SUBMITTER: Shelton JM 

PROVIDER: S-EPMC4552443 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature