Ontology highlight
ABSTRACT:
SUBMITTER: Gamazon ER
PROVIDER: S-EPMC4552594 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Gamazon Eric R ER Wheeler Heather E HE Wheeler Heather E HE Shah Kaanan P KP Mozaffari Sahar V SV Aquino-Michaels Keston K Carroll Robert J RJ Eyler Anne E AE Denny Joshua C JC Nicolae Dan L DL Cox Nancy J NJ Im Hae Kyung HK
Nature genetics 20150810 9
Genome-wide association studies (GWAS) have identified thousands of variants robustly associated with complex traits. However, the biological mechanisms underlying these associations are, in general, not well understood. We propose a gene-based association method called PrediXcan that directly tests the molecular mechanisms through which genetic variation affects phenotype. The approach estimates the component of gene expression determined by an individual's genetic profile and correlates 'imput ...[more]