Ontology highlight
ABSTRACT:
SUBMITTER: Bakshi A
PROVIDER: S-EPMC5015118 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Scientific reports 20160908
We propose a method (fastBAT) that performs a fast set-based association analysis for human complex traits using summary-level data from genome-wide association studies (GWAS) and linkage disequilibrium (LD) data from a reference sample with individual-level genotypes. We demonstrate using simulations and analyses of real datasets that fastBAT is more accurate and orders of magnitude faster than the prevailing methods. Using fastBAT, we analyze summary data from the latest meta-analyses of GWAS ...[more]