Dataset Information

Physical function impairment of older, HIV-infected adults is associated with cytomegalovirus immunoglobulin response.

ABSTRACT: Cytomegalovirus (CMV) is associated with poor outcomes, including physical function impairment, in older HIV-uninfected adults. Whether CMV is associated with physical functional impairment in HIV-infected adults is unknown. The primary objective of this study was to determine the relationship between CMV-specific humoral and cell-mediated immune responses with functional impairment in well-controlled HIV infection. In a case-control study, low-function cases were matched by age, gender, and time from HIV diagnosis to high-function controls. Quantitative CMV IgG and %CMV-specific CD8(+) and CD4(+) T cells (interferon-? expression following CMV pp65 stimulation) were used to estimate physical function. Among 30?low-function cases and 48 high-function matched controls, CMV IgG ranged from <10 to 8,830?EU/ml, including four controls with results <10?EU/ml. Each log10 increase in CMV IgG was associated with 5-fold greater odds of low function (p=0.01); these findings were robust to adjustment for concomitant CD4(+) count, tobacco use, and age; to exclusion of subjects with CMV IgG <10?EU/ml; and to adjustment for hepatitis C viremia. %CMV-specific CD4(+) or CD8(+) T cells were not associated with low function. In bivariable models, the relationship between CMV IgG and physical function was attenuated and was no longer significant when including IL-6, CD4/CD8 ratio, or the Veterans Aging Cohort Study Index score. High levels of CMV-specific IgG were associated with impaired physical function. Attenuation of the strength of this association in bivariable models suggests an indirect relationship mediated by systemic inflammation and immune suppression.

SUBMITTER: Erlandson KM

PROVIDER: S-EPMC4553372 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature

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Physical function impairment of older, HIV-infected adults is associated with cytomegalovirus immunoglobulin response.

Erlandson Kristine M KM Allshouse Amanda A AA Rapaport Eric E Palmer Brent E BE Wilson Cara C CC Weinberg Adriana A MaWhinney Samantha S Campbell Thomas B TB

AIDS research and human retroviruses 20150708 9

Cytomegalovirus (CMV) is associated with poor outcomes, including physical function impairment, in older HIV-uninfected adults. Whether CMV is associated with physical functional impairment in HIV-infected adults is unknown. The primary objective of this study was to determine the relationship between CMV-specific humoral and cell-mediated immune responses with functional impairment in well-controlled HIV infection. In a case-control study, low-function cases were matched by age, gender, and tim ...[more]

PMID: 26061347

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Dataset Information

Physical function impairment of older, HIV-infected adults is associated with cytomegalovirus immunoglobulin response.

Publications

Physical function impairment of older, HIV-infected adults is associated with cytomegalovirus immunoglobulin response.

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