Ontology highlight
ABSTRACT:
SUBMITTER: Snyder CA
PROVIDER: S-EPMC4556269 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Snyder Chelsea A CA Goodson Michael L ML Schroeder Amy C AC Privalsky Martin L ML
Molecular and cellular endocrinology 20150710
Alternative mRNA splicing diversifies the products encoded by the NCoR and SMRT corepressor loci. There is a programmed alteration in NCoR mRNA splicing during adipocyte differentiation from an NCoRω isoform, which contains three nuclear receptor interaction domains, to an NCoRδ isoform that contains two nuclear receptor interaction domains. This alternative mRNA splicing of NCoR has profound effects on adiposity and on diabetes in mouse models. We report here that dexamethasone, a powerful regu ...[more]