Ontology highlight
ABSTRACT:
SUBMITTER: Yoon JH
PROVIDER: S-EPMC4556280 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Yoon Je-Hyun JH Abdelmohsen Kotb K Kim Jiyoung J Yang Xiaoling X Martindale Jennifer L JL Tominaga-Yamanaka Kumiko K White Elizabeth J EJ Orjalo Arturo V AV Rinn John L JL Kreft Stefan G SG Wilson Gerald M GM Gorospe Myriam M
Nature communications 20130101
Although mammalian long non-coding (lnc)RNAs are best known for modulating transcription, their post-transcriptional influence on mRNA splicing, stability and translation is emerging. Here we report a post-translational function for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis. HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR ...[more]