Ontology highlight
ABSTRACT:
SUBMITTER: Bahl CD
PROVIDER: S-EPMC4556431 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Bahl Christopher D CD Hvorecny Kelli L KL Bomberger Jennifer M JM Stanton Bruce A BA Hammock Bruce D BD Morisseau Christophe C Madden Dean R DR
Angewandte Chemie (International ed. in English) 20150701 34
Opportunistic pathogens exploit diverse strategies to sabotage host defenses. Pseudomonas aeruginosa secretes the CFTR inhibitory factor Cif and thus triggers loss of CFTR, an ion channel required for airway mucociliary defense. However, the mechanism of action of Cif has remained unclear. It catalyzes epoxide hydrolysis, but there is no known role for natural epoxides in CFTR regulation. It was demonstrated that the hydrolase activity of Cif is strictly required for its effects on CFTR. A small ...[more]