Knotted proteins: A tangled tale of Structural Biology.
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ABSTRACT:
SUBMITTER: Faisca PF
PROVIDER: S-EPMC4556803 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Publications
Knotted proteins: A tangled tale of Structural Biology.
Computational and structural biotechnology journal 20150819
Knotted proteins have their native structures arranged in the form of an open knot. In the last ten years researchers have been making significant efforts to reveal their folding mechanism and understand which functional advantage(s) knots convey to their carriers. Molecular simulations have been playing a fundamental role in this endeavor, and early computational predictions about the knotting mechanism have just been confirmed in wet lab experiments. Here we review a collection of simulation r ...[more]
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