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Cutting Edge: Developmental Regulation of IFN-? Production by Mouse Neutrophil Precursor Cells.

ABSTRACT: Neutrophils are an emerging cellular source of IFN-?, a key cytokine that mediates host defense to intracellular pathogens. Production of IFN-? by neutrophils, in contrast to lymphoid cells, is TLR- and IL-12-independent and the events associated with IFN-? production by neutrophils are not understood. In this study, we show that mouse neutrophils express IFN-? during their lineage development in the bone marrow niche at the promyelocyte stage independently of microbes. IFN-? accumulates in primary neutrophilic granules and is released upon induction of degranulation. The developmental mechanism of IFN-? production in neutrophils arms the innate immune cells prior to infection and assures the potential for rapid release of IFN-? upon neutrophil activation, the first step during responses to many microbial infections.

SUBMITTER: Sturge CR

PROVIDER: S-EPMC4557207 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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Cutting Edge: Developmental Regulation of IFN-γ Production by Mouse Neutrophil Precursor Cells.

Sturge Carolyn R CR Burger Elise E Raetz Megan M Hooper Lora V LV Yarovinsky Felix F

Journal of immunology (Baltimore, Md. : 1950) 20150529 1

Neutrophils are an emerging cellular source of IFN-γ, a key cytokine that mediates host defense to intracellular pathogens. Production of IFN-γ by neutrophils, in contrast to lymphoid cells, is TLR- and IL-12-independent and the events associated with IFN-γ production by neutrophils are not understood. In this study, we show that mouse neutrophils express IFN-γ during their lineage development in the bone marrow niche at the promyelocyte stage independently of microbes. IFN-γ accumulates in prim ...[more]

PMID: 26026057

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