Ontology highlight
ABSTRACT:
SUBMITTER: Yadav D
PROVIDER: S-EPMC2714222 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Yadav Deepak D Ngolab Jennifer J Lim Rod Seung-Hwan RS Krishnamurthy Siddharth S Bui Jack D JD
Journal of immunology (Baltimore, Md. : 1950) 20090101 1
NKG2D is a receptor used by NK cells to detect virally infected and transformed cells. It recognizes ligands that are expressed constitutively on primary tumors and tumor cell lines. In this report, we have identified four microRNAs (miRNAs) that each was sufficient to reduce the expression of the NKG2D ligand MHC class I-related chain A (MICA). One of these miRNAs (miR-520b) was induced by IFN-gamma, leading to a reduction in MICA surface protein levels. Interestingly, miR-520b acted on both th ...[more]