Ontology highlight
ABSTRACT:
SUBMITTER: Osman AA
PROVIDER: S-EPMC4557970 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Osman Abdullah A AA Monroe Marcus M MM Ortega Alves Marcus V MV Patel Ameeta A AA Katsonis Panagiotis P Fitzgerald Alison L AL Neskey David M DM Frederick Mitchell J MJ Woo Sang Hyeok SH Caulin Carlos C Hsu Teng-Kuei TK McDonald Thomas O TO Kimmel Marek M Meyn Raymond E RE Lichtarge Olivier O Myers Jeffrey N JN
Molecular cancer therapeutics 20141210 2
Although cisplatin has played a role in "standard-of-care" multimodality therapy for patients with advanced squamous cell carcinoma of the head and neck (HNSCC), the rate of treatment failure remains particularly high for patients receiving cisplatin whose tumors have mutations in the TP53 gene. We found that cisplatin treatment of HNSCC cells with mutant TP53 leads to arrest of cells in the G2 phase of the cell cycle, leading us to hypothesize that the wee-1 kinase inhibitor MK-1775 would abrog ...[more]