Ontology highlight
ABSTRACT:
SUBMITTER: Hsu WH
PROVIDER: S-EPMC6534433 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Hsu Wei-Hsun WH Zhao Xiaoliang X Zhu Jianquan J Kim In-Kyu IK Rao Guanhua G McCutcheon Justine J Hsu Shuo-Tse ST Teicher Beverly B Kallakury Bhaskar B Dowlati Afshin A Zhang Yu-Wen YW Giaccone Giuseppe G
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20190214 6
<h4>Introduction</h4>Platinum-based chemotherapy remains the standard treatment for patients with SCLC, but the benefit of the treatment is often hampered by rapid development of drug resistance. Thus far, there is no targeted therapy available for SCLC. More than 90% of SCLC tumors harbor mutations in the tumor suppressor gene tumor protein p53 (p53), an important DNA damage checkpoint regulator, and these tumor cells rely predominantly on the checkpoint kinases to control DNA damage response.< ...[more]