Ontology highlight
ABSTRACT:
SUBMITTER: Gu Y
PROVIDER: S-EPMC4558139 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Gu Ying Y Zhou Hong H Gan Yichao Y Zhang Jiawei J Chen Jianghua J Gan Xiaoxian X Li Hongzhi H Zheng Weiwei W Meng Zhipeng Z Ma Xiaoxiao X Wang Xichun X Xu Xiaohua X Xu Ganyu G Lu Xiaoya X Liang Yun Y Zhang Xuzhao X Lu Xinliang X Huang Wendong W Xu Rongzhen R
Oncotarget 20150601 17
As phospho-eIF4E (p-eIF4E), unlike total eIF4E (t-eIF4E) essential for normal cells, is specifically required by cancer cells, it is an attractive, yet unrealized, target for anti-tumor intervention. Here we identify a small molecule, homoharringtonine (HHT), that antagonizes p-eIF4E function and eradicates acute myeloid leukemia (AML) expressing high level of p-eIF4E in vitro and in vivo. HHT selectively reduces p-eIF4E levels of leukemia cells without affecting t-eIF4E. HHT targets the phospho ...[more]