Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC4558141 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Li Hua H Mohamed Ahmed A AA Sharad Shashwat S Umeda Elizabeth E Song Yingjie Y Young Denise D Petrovics Gyorgy G McLeod David G DG Sesterhenn Isabell A IA Sreenath Taduru T Dobi Albert A Srivastava Shiv S
Oncotarget 20150601 17
Androgen Receptor (AR) is the male hormone receptor and a nuclear transcription factor which plays a central role in the growth of normal and malignant prostate gland. Our earlier studies defined a mechanistic model for male hormone dependent regulation of AR protein levels in prostate cancer (CaP) cells through a negative feed-back loop between AR and PMEPA1, an androgen induced NEDD4 E3 ubiquitin ligase binding protein. This report focuses on the impact of PMEPA1 silencing on CaP biology. PMEP ...[more]