GABARAPL1 Promotes AR+ Prostate Cancer Growth by Increasing FL-AR/AR-V Transcription Activity and Nuclear Translocation.
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ABSTRACT:
SUBMITTER: Su B
PROVIDER: S-EPMC6872515 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
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GABARAPL1 Promotes AR+ Prostate Cancer Growth by Increasing FL-AR/AR-V Transcription Activity and Nuclear Translocation.
Su Bing B Zhang Lijuan L Liu Shenglin S Chen Xiaofan X Zhang Wei W
Frontiers in oncology 20191115
The next generation Androgen receptor (AR)-targeted therapies are now in widespread clinical use and prolong prostate cancer (CaP) patient survival. However, the therapies are not curative due to diverse range of resistance mechanisms. AR variants (AR-V), one major mechanism of resistance, has recently gained momentum. Here, we found that GABARAPL1 knockdown inhibits the growth of AR-positive LNCaP and CWR22rv1 CaP cells <i>in vitro</i> and <i>in vivo</i>, decreases AR/AR-V transcription activit ...[more]
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