Ontology highlight
ABSTRACT:
SUBMITTER: Taube JM
PROVIDER: S-EPMC4558237 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Taube Janis M JM Young Geoffrey D GD McMiller Tracee L TL Chen Shuming S Salas January T JT Pritchard Theresa S TS Xu Haiying H Meeker Alan K AK Fan Jinshui J Cheadle Chris C Berger Alan E AE Pardoll Drew M DM Topalian Suzanne L SL
Clinical cancer research : an official journal of the American Association for Cancer Research 20150505 17
<h4>Purpose</h4>Blocking the immunosuppressive PD-1/PD-L1 pathway has antitumor activity in multiple cancer types, and PD-L1 expression on tumor cells and infiltrating myeloid cells correlates with the likelihood of response. We previously found that IFNG (interferon-gamma) was overexpressed by tumor-infiltrating lymphocytes in PD-L1(+) versus PD-L1(-) melanomas, creating adaptive immune resistance by promoting PD-L1 display. This study was undertaken to identify additional factors in the PD-L1( ...[more]