Ontology highlight
ABSTRACT:
SUBMITTER: Srikanth P
PROVIDER: S-EPMC4558300 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Srikanth Priya P Han Karam K Callahan Dana G DG Makovkina Eugenia E Muratore Christina R CR Lalli Matthew A MA Zhou Honglin H Boyd Justin D JD Kosik Kenneth S KS Selkoe Dennis J DJ Young-Pearse Tracy L TL
Cell reports 20150820 9
Genetic and clinical association studies have identified disrupted in schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness. DISC1 is interrupted by a balanced chr(1;11) translocation in a Scottish family in which the translocation predisposes to psychiatric disorders. We investigate the consequences of DISC1 interruption in human neural cells using TALENs or CRISPR-Cas9 to target the DISC1 locus. We show that disruption of DISC1 near the site of the translocation results in ...[more]