Ontology highlight
ABSTRACT:
SUBMITTER: Mimoto MS
PROVIDER: S-EPMC4641806 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Mimoto Mizuho S MS Kwon Sunjong S Green Yangsook Song YS Goldman Devorah D Christian Jan L JL
Developmental biology 20150910 1
Primitive erythropoiesis is regulated in a non cell-autonomous fashion across evolution from frogs to mammals. In Xenopus laevis, signals from the overlying ectoderm are required to induce the mesoderm to adopt an erythroid fate. Previous studies in our lab identified the transcription factor GATA2 as a key regulator of this ectodermal signal. To identify GATA2 target genes in the ectoderm required for red blood cell formation in the mesoderm, we used microarray analysis to compare gene expressi ...[more]