MiR-526b targets 3' UTR of MMP1 mRNA.
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ABSTRACT:
SUBMITTER: Kim KH
PROVIDER: S-EPMC4558487 | biostudies-literature | 2015 Aug
REPOSITORIES: biostudies-literature
Publications
miR-526b targets 3' UTR of MMP1 mRNA.
Kim Kyu-Han KH Jung Ji-Yong JY Son Eui Dong ED Shin Dong Wook DW Noh Minsoo M Lee Tae Ryong TR
Experimental & molecular medicine 20150821
Regulation of matrix metalloproteinases (MMPs) is important for many physiological processes involving cancers, inflammation, tissue remodeling and skin aging. Here, we report the novel finding that the expression of MMP1 mRNA is downregulated by the overexpression of miR-526b which is a member of chromosome 19 microRNA cluster (C19MC). Our analysis using reporter constructs containing the 3' untranslated region (3' UTR) of MMP1 and its mutant form showed that the region from 377-383 in the 3' U ...[more]
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