Ontology highlight
ABSTRACT:
SUBMITTER: Marshall JE
PROVIDER: S-EPMC4558608 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Marshall Jamie E JE Faraj Bayan H A BH Gingras Alexandre R AR Lonnen Rana R Sheikh Md Arif MA El-Mezgueldi Mohammed M Moody Peter C E PC Andrew Peter W PW Wallis Russell R
Scientific reports 20150903
Pneumolysin is a cholesterol-dependent cytolysin (CDC) and virulence factor of Streptococcus pneumoniae. It kills cells by forming pores assembled from oligomeric rings in cholesterol-containing membranes. Cryo-EM has revealed the structures of the membrane-surface bound pre-pore and inserted-pore oligomers, however the molecular contacts that mediate these oligomers are unknown because high-resolution information is not available. Here we have determined the crystal structure of full-length pne ...[more]