Ontology highlight
ABSTRACT:
SUBMITTER: Lawrence SL
PROVIDER: S-EPMC4585913 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Scientific reports 20150925
Pore-forming proteins are weapons often used by bacterial pathogens to breach the membrane barrier of target cells. Despite their critical role in infection important structural aspects of the mechanism of how these proteins assemble into pores remain unknown. Streptococcus pneumoniae is the world's leading cause of pneumonia, meningitis, bacteremia and otitis media. Pneumolysin (PLY) is a major virulence factor of S. pneumoniae and a target for both small molecule drug development and vaccines. ...[more]