Ontology highlight
ABSTRACT:
SUBMITTER: Espinosa DA
PROVIDER: S-EPMC4559189 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Espinosa Diego A DA Gutierrez Gabriel M GM Rojas-López Maricarmen M Noe Amy R AR Shi Lirong L Tse Sze-Wah SW Sinnis Photini P Zavala Fidel F
The Journal of infectious diseases 20150311 7
Studies in animals and human volunteers demonstrate that antibodies against the repeat-region of the Plasmodium circumsporozoite protein (CSP) abrogate sporozoite infection. However, the realization that the N- and C- terminal regions flanking the repeats play essential roles in parasite infectivity raised the possibility that they could be targeted by protective antibodies. We characterized a monoclonal antibody (mAb5D5) specific for the N-terminus of the P. falciparum CSP, which inhibits the p ...[more]