Ontology highlight
ABSTRACT:
SUBMITTER: Manjurano A
PROVIDER: S-EPMC4559194 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Manjurano Alphaxard A Sepúlveda Nuno N Nadjm Behzad B Mtove George G Wangai Hannah H Maxwell Caroline C Olomi Raimos R Reyburn Hugh H Drakeley Christopher J CJ Riley Eleanor M EM Clark Taane G TG
The Journal of infectious diseases 20150324 7
Populations exposed to Plasmodium falciparum infection develop genetic mechanisms of protection against severe malarial disease. Despite decades of genetic epidemiological research, the sickle cell trait (HbAS) sickle cell polymorphism, ABO blood group, and other hemoglobinopathies remain the few major determinants in severe malaria to be replicated across different African populations and study designs. Within a case-control study in a region of high transmission in Tanzania (n = 983), we inves ...[more]