Candidate polymorphisms and severe malaria in a Malian population.
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ABSTRACT:
SUBMITTER: Toure O
PROVIDER: S-EPMC3434208 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Candidate polymorphisms and severe malaria in a Malian population.
Toure Ousmane O Konate Salimata S Sissoko Sibiri S Niangaly Amadou A Barry Abdoulaye A Sall Abdourahmane H AH Diarra Elisabeth E Poudiougou Belco B Sepulveda Nuno N Campino Susana S Rockett Kirk A KA Clark Taane G TG Thera Mahamadou A MA Doumbo Ogobara O
PloS one 20120905 9
Malaria is a major health burden in sub-Saharan African countries, including Mali. The disease is complex, with multiple genetic determinants influencing the observed variation in response to infection, progression, and severity. We assess the influence of sixty-four candidate loci, including the sickle cell polymorphism (HbS), on severe malaria in a case-control study consisting of over 900 individuals from Bamako, Mali. We confirm the known protective effects of the blood group O and the HbS A ...[more]
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