Ontology highlight
ABSTRACT:
SUBMITTER: Platzer B
PROVIDER: S-EPMC4559493 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Platzer Barbara B Elpek Kutlu G KG Cremasco Viviana V Baker Kristi K Stout Madeleine M MM Schultz Cornelia C Dehlink Eleonora E Shade Kai-Ting C KC Anthony Robert M RM Blumberg Richard S RS Turley Shannon J SJ Fiebiger Edda E
Cell reports 20150305 9
Epidemiologic studies discovered an inverse association between immunoglobulin E (IgE)-mediated allergies and cancer, implying tumor-protective properties of IgE. However, the underlying immunologic mechanisms remain poorly understood. Antigen cross-presentation by dendritic cells (DCs) is of key importance for anti-tumor immunity because it induces the generation of cytotoxic CD8<sup>+</sup> T lymphocytes (CTLs) with specificity for tumor antigens. We demonstrate that DCs use IgE and FcεRI, the ...[more]