Ontology highlight
ABSTRACT:
SUBMITTER: Ghosh M
PROVIDER: S-EPMC3358354 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Ghosh Mallika M McAuliffe Beata B Subramani Jaganathan J Basu Sreyashi S Shapiro Linda H LH
Journal of immunology (Baltimore, Md. : 1950) 20120427 11
Dendritic cell (DC) Ag cross-presentation is generally associated with immune responses to tumors and viral Ags, and enhancement of this process is a focus of tumor vaccine design. In this study, we found that the myeloid cell surface peptidase CD13 is highly and specifically expressed on the subset of DCs responsible for cross-presentation, the CD8(+) murine splenic DCs. In vivo studies indicated that lack of CD13 significantly enhanced T cell responses to soluble OVA Ag, although development, ...[more]